Antitrypanosomal and Antileishmanial Activity of Chalcones and Flavanones from Polygonum salicifolium

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dc.contributor.authorZheoat, Ahmed M.
dc.contributor.authorAlenezi, Samya
dc.contributor.authorElmahallawy, Ehab Kotb
dc.date.accessioned2023-04-26T16:21:51Z
dc.date.available2023-04-26T16:21:51Z
dc.date.issued2021-02-05
dc.descriptionPathogens 2021, 10, 175.en_US
dc.description.abstractTrypanosomiasis and leishmaniasis are a group of neglected parasitic diseases caused by several species of parasites belonging to the family Trypansomatida. The present study investigated the antitrypanosomal and antileishmanial activity of chalcones and flavanones from Polygonum salicifolium, which grows in the wetlands of Iraq. The phytochemical evaluation of the plant yielded two chalcones, 20,40-dimethoxy-60-hydroxychalcone and 20,50-dimethoxy-40,60-dihydroxychalcone, and two flavanones, 5,7-dimethoxyflavanone and 5,8-dimethoxy-7-hydroxyflavanone. The chalcones showed a good antitrypanosomal and antileishmanial activity while the flavanones were inactive. The EC50 values for 20,40-dimethoxy-60-hydroxychalcone against Trypanosoma brucei brucei (0.5 g/mL), T. congolense (2.5 g/mL), and Leishmania mexicana (5.2 g/mL) indicated it was the most active of the compounds. None of the compounds displayed any toxicity against a human cell line, even at 100 g/mL, or crossresistancewith first line clinical trypanocides, such as diamidines andmelaminophenyl arsenicals. Taken together, our study provides significant data in relation to the activity of chalcones and flavanones from P. salicifolium against both parasites in vitro. Further future research is suggested in order to investigate the mode of action of the extracted chalcones against the parasites.en_US
dc.description.sponsorshipACE Impact: Food Technology and Research, CEFTERen_US
dc.description.urihttps://doi.org/10.3390/pathogens10 020175en
dc.identifier.citationhttps://doi.org/10.3390/pathogens10 020175en_US
dc.identifier.issn0000-0000
dc.identifier.issn1530-261X
dc.identifier.urihttp://hdl.handle.net/123456789/1605
dc.identifier.urihttps://doi.org/10.3390/pathogens10020175en
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.subjectPolygonum salicifoliumen_US
dc.subjectchalconeen_US
dc.subjectflavanoneen_US
dc.subjectLeishmania mexicanaen_US
dc.subjectTrypanosoma brucei bruceien_US
dc.subjectTrypanosoma congolenseen_US
dc.subjectMarzuq A. Ungogoen_US
dc.subjectAli H. Alghamdien_US
dc.subjectDavid G. Watsonen_US
dc.subjectJohn O. Igolien_US
dc.subjectAlexander I. Grayen_US
dc.subjectHarry P. de Koningen_US
dc.subjectValerie A. Ferroen_US
dc.subjectUniversity of Agricultureen_US
dc.subjectNigeriaen_US
dc.subjectCEFTERen_US
dc.titleAntitrypanosomal and Antileishmanial Activity of Chalcones and Flavanones from Polygonum salicifoliumen_US
dc.typeArticleen_US
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